herbicide

December 4, 2024

Study indicates “persistent, damaging” effects of glyphosate herbicide exposure on brain health

By Carey Gillam

Exposure to a widely used weed killing chemical could be having “persistent, damaging effects” on brain health, according to a new study.

The study, published Wednesday in the Journal of Neuroinflammation, found that laboratory mice exposed to glyphosate herbicide developed significant brain inflammation, a condition associated with neurodegenerative diseases such as Alzheimer’s. The researchers, many who are associated with a neurodegenerative disease research center at Arizona State University (ASU), said the symptoms continued even long after exposure ended.

“This work is yet another step forward in understanding the impact of this widely used herbicide on the brain,” lead ASU researcher Ramon Velazquez said. “But more research is needed to determine the impact that glyphosate has on the brain since most Americans are exposed to this herbicide on a daily basis.” Velazquez noted that the work is particularly important given the increasing incidence of cognitive decline in the aging population, particularly in rural communities where glyphosate is used in farming.

Glyphosate is the most commonly used herbicide globally – made popular by Monsanto Co as the active ingredient in its Roundup brand, among others. It has been used so extensively by farmers, homeowners and industrial and municipal users for so long that it is considered ubiquitous – found in food, water and in human urine samples. A 2022 report by a unit of the Centers for Disease Control and Prevention (CDC) said more than 80% of urine samples drawn from children and adults in a US health study contained glyphosate.

Several authors of the new paper were also part of a team that published a prior, related study that examined the impact of glyphosate when it infiltrates the brain.

October 22, 2024

EPA cancels pesticide shown to be harmful to unborn babies

By Carey Gillam

Citing a need to protect the unborn babies of pregnant women, the US Environmental Protection Agency (EPA) on Tuesday banned a pesticide used to kill weeds on farms, golf courses and athletic fields.

The action comes after years of mounting scientific evidence of the dangers posed by exposure to the chemical dimethyl tetrachloroterephthalate, also known as DCPA or Dacthal.

“With the final cancellation of DCPA, we’re taking a definitive step to protect pregnant women and their unborn babies,” Michal Freedhoff, assistant administrator for the EPA Office of Chemical Safety and Pollution Prevention, said in a press release. “The science showing the potential for irreversible harm to unborn babies’ developing brains, in addition to other lifelong consequences from exposure, demands decisive action to remove this dangerous chemical from the marketplace.”

The agency said “robust studies” demonstrated “thyroid toxicity,” and said that unborn babies whose pregnant mothers are exposed to DCPA could experience changes to fetal thyroid hormone levels. Such changes are “generally linked to low birth weight, impaired brain development, decreased IQ, and impaired motor skills later in life, some of which may be irreversible,” the EPA said.

DCPA was registered to control weeds in both agricultural and non-agricultural settings, but has largely been used to control weeds in fields growing crops such as broccoli, brussels sprouts, cabbage and onions.

July 25, 2024

Pesticide exposure as risky as smoking, study finds

By Shannon Kelleher

People who don’t farm, but live in US agricultural communities where pesticides are used on farms, face an increased cancer risk as significant as if they were smokers, according to a new study.

The study, published July 25 in the journal Frontiers in Cancer Control and Society, analyzed cancer incidence data from nearly every US county and looked at how that data corresponded to federal data on agricultural pesticide use. Researchers reported that they found the higher the pesticide use, the higher the risk for every type of cancer the researchers looked at.

“Agricultural pesticide usage has a significant impact on all the cancer types evaluated in this study (all cancers, bladder cancer, colon cancer, leukemia, lung cancer, non-Hodgkin’s lymphoma, and pancreatic cancer); and these associations are more evident in regions with heavy agricultural productivity,” the study states.

“Pesticide-associated cancers appear to be on par for several smoking-associated cancer types,” the study states. It has been well established that smoking increases cancer risk, with at least 70 of the thousands of chemicals in tobacco smoke considered carcinogens.

The findings add to a wealth of research on pesticides and human health risks that point to shortcomings in US pesticide regulations, said Dana Barr, and environmental health researcher at Emory University who was not involved in the study.

“Right now, I don’t think the regulations for pesticides are the most health-protective, and they seem to presume that a chemical is safe until it is proven toxic, not the other way around,” she said. “I do think we need policy reform that puts the onus on the manufacturers to do a better job of evaluating safety before allowing new registrations.”

July 11, 2024

Monsanto Roundup trial win overturned by Oregon court

By Carey Gillam

An Oregon appeals court on Wednesday overturned a trial victory by Monsanto owner Bayer AG in a decision that adds to an ongoing debate over the company’s efforts to create a nationwide legal and legislative shield from lawsuits alleging Roundup weed killer causes cancer.

The court found that the trial judge in the case improperly barred key evidence about the US Environmental Protection Agency (EPA) from being presented to the jury, which could have led the jury to find in favor of the plaintiff. And, notably, the court rejected arguments by the company that claims about the dangers of its products should be barred because those products carry the EPA’s stamp of approval.

Other courts have similarly rejected so-called “preemption” arguments by Bayer, which bought Monsanto in 2018. But after failing to get court backing, Bayer has been pushing state and federal lawmakers to give it and other pesticide makers the protection the courts have rejected. A proposed measure is being considered by lawmakers for inclusion in the US Farm Bill. Monsanto unsuccessfully argued to the appeals court that the case never should have even gone to a jury because the claims should have been preempted.

Bayer did not respond to a request for comment on the latest ruling.

Attorney Andrew Kirkendall, who represented the plaintiff in the case, said he welcomed the court’s decision and was eager to retry the case with the evidence about the EPA included.

The testimony that the trial judge refused to allow was to have come from Charles Benbrook, a former research professor who served at one time as executive director of the National Academy of Sciences board on agriculture. Benbrook has authored papers critical of the EPA’s handling of glyphosate herbicides, noting that the agency has given little weight to independent research regarding the actual products sold into the marketplace and used by millions of people around the world. Instead, the EPA has mostly relied on studies paid for by Monsanto and other companies selling glyphosate herbicides that found no cancer concerns.

“There is important new science to share with the jury that clarifies why and how Roundup can cause cancer,” Benbrook said this week after learning of the court ruling.

May 30, 2024

Paraquat ban stays alive, advances in California

By Carey Gillam

A proposal to ban the weed killing chemical paraquat cleared the California State Assembly last week and now faces a fight in the State Senate over what would be the first such ban in the country.

The ban would take effect Jan. 1, 2026, outlawing the “use, manufacture, sale, delivery, holding, or offering for sale in commerce” of any pesticide product that contains paraquat. The bill provides for a process that allows state regulators to reevaluate paraquat and potentially reapprove it with or without new restrictions.

A chief concern cited by backers of the bill is research linking chronic paraquat exposure to Parkinson’s disease, an incurable and debilitating brain disease considered a top cause of death in the United States.

The final vote in the Assembly was 46-16 in favor of the bill, but opposition is expected to be stronger in the Senate, according to staffers with the office of Assemblymember Laura Friedman, who introduced the measure. California’s Senate Policy Committee is expected to take it up sometime before July 4, they said.

Friedman partnered with the Environmental Working Group (EWG) to introduce the proposed ban. An EWG analysis found that paraquat is disproportionately sprayed in areas of California largely inhabited by Latino farmworkers and their families.

The action to ban paraquat in California comes as several thousand farmers, agricultural workers and others are suing paraquat maker Syngenta, alleging they developed Parkinson’s because of long-term chronic effects of paraquat.

April 18, 2024

“Sustainable” company behind POM juice among California’s top paraquat sprayers

By Shannon Kelleher

The Wonderful Company, which has been recognized for its sustainability initiatives and owns POM pomegranate juice, Fiji Water, and other popular brands, was among California’s top sprayers of the toxic weedkiller paraquat in 2021, according to a new analysis.

The major agricultural company, which grows pistachios, almonds, and pomegranates, was California’s second largest sprayer of paraquat, which has been linked to Parkinson’s disease. Wonderful accounted for over 13% of the state’s paraquat use, applying almost 57,000 lbs to its fields, according to the analysis published Thursday by the Environmental Working Group (EWG), which drew from data obtained from the California Department of Pesticide Regulation and county agriculture commissioners.

The company’s website states that “environmental sustainability is at the center of our work” and that the company, “in all its operations, must be a deeply responsible steward of the environment, and lead by example to create a sustainable future.” Wonderful has invested $400 million in sustainable agriculture, according to its website.

The Wonderful Company did not immediately respond to request for comment.

Just ten farms and companies in the top agricultural state sprayed 40% of all paraquat used in California in 2021, the analysis found. The biggest paraquat user in the state was the J.G. Boswell Company, a major producer of cotton, tomatoes for paste, and seed crops, which also accounted for over 13% of California’s paraquat use that year.

“Folks have known about paraquat for a while…but I think it’s clear the public doesn’t fully appreciate where these pesticides are being applied and how close it is to their communities,” said Geoff Horsfield, a policy director at the Environmental Working Group who works on pesticides and other agricultural issues.

April 1, 2024

Concerned about developing babies, EPA warns about danger of weed killer used on farms, golf courses

By Johnathan Hettinger

The US Environmental Protection Agency (EPA) on Monday took the rare step of issuing a warning about “serious, permanent, and irreversible health risks” associated with a chemical used to kill weeds on farms and golf courses and athletic fields.

Citing “significant health risks to pregnant individuals and their developing babies,” the agency said farmworkers and others handling dimethyl tetrachloroterephthalate, more commonly known as DCPA, were at risk, as are people who might play on courses or fields recently sprayed with the pesticide.

The most serious risks extend to the developing babies of pregnant women, especially those handling DCPA products. The agency said pregnant women exposed to DCPA could experience changes to fetal thyroid hormone levels, which are linked to low birth weight, impaired brain development, decreased IQ, and impaired motor skills later in life. Though product labels say people should stay out of fields for 12 hours after they are sprayed with DCPA, the EPA said evidence indicates that in many cases, sprayed fields would be unsafe for 25 days or more. The agency additionally said that mothers and their developing babies could be at risk if they live near areas where DCPA is used because the pesticide can drift.

“EPA has determined that currently registered products containing the herbicide DCPA likely cannot be used under current label directions without posing serious risks of concern in humans,” Ed Messina, director of the Office of Pesticide Programs, stated in a letter to AMVAC, a California-based company that is the sole manufacturer of the pesticide.

The product is primarily used to control weeds on crops such as broccoli, Brussels sprouts, cabbage and onions, though it is also used in some non-agricultural settings. Last year, AMVAC agreed to end its use on turf, citing health concerns.

The EPA is currently reviewing whether to reapprove DCPA. Though the agency rarely takes the step of canceling a pesticide, it is considering that route, including suspending DCPA during review process, the agency said.

“Due to the serious potential risks posed by DCPA use, EPA will be pursuing these regulatory options as soon as practicable,” Messina wrote in the communication to AMVAC.

September 5, 2023

Letter from the editor: The saga of Syngenta, a scientist, and a subpoena

By Carey Gillam

Six months ago neurologist Dr. E. Ray Dorsey and a colleague authored an article titled “Paraquat, Parkinson’s Disease and Agnotology,” which spotlighted secrets unearthed from within the corporate files of paraquat maker Syngenta AG. The article was published March 6, 2023, in Movement Disorders, the official journal of the International Parkinson and Movement Disorder Society.

In the article, Dorsey and co-author neurologist Dr. Amit Ray pointed to stories I wrote for The New Lede and The Guardian that were based upon thousands of pages of the company’s internal documents dating back to the 1950s. Those files revealed many corporate secrets related to paraquat safety and the weed killer’s potential connection to the dreaded, incurable brain disease known as Parkinson’s.

“Knowledge of the toxic effects of paraquat is alleged to have been hidden for decades,” Dorsey’s article stated. “All the while, the manufacturer continues to maintain that paraquat does not cause Parkinson’s disease. Actions like these should be recognized for what they are: attacks on science, attacks on scientists, and attacks on the health of the public.”

“This report and the company’s own findings now indicate that we know what one cause of Parkinson’s disease is—paraquat,” the article stated. “With this conclusion, paraquat should be banned, and the search for other causative factors in the environment should accelerate.”

(Dr. E. Ray Dorsey)
The statements published in the article did not sit well with Syngenta, to put it mildly.

Syngenta has spent the last few months engaging in what Dorsey’s defenders say is the latest effort in a history of chemical industry actions to harass, or otherwise smear, scientists whose work threatens corporate interests.

Since the article’s publication, Syngenta has been demanding that Dorsey turn over his private files – emails, notes, article drafts, and other records. The company is publicly accusing Dorsey of publishing his article not as a sincere scientific commentary, but as part of a conspiracy to engineer evidence that could be used by plaintiffs in sweeping, nationwide litigation brought by people alleging they developed Parkinson’s because of exposure to Syngenta’s paraquat herbicide.

After Dorsey balked at Syngenta’s demands, citing the fact that he has no connection to the litigation, the company last month asked a federal judge to force Dorsey to turn over his files.

August 22, 2023

Science takes center stage in court hearing over paraquat and Parkinson’s disease

By Carey Gillam

Testimony is underway this week in a key federal court hearing aimed at examining scientific evidence about allegations that a widely used weedkiller called paraquat causes Parkinson’s disease.

The outcome of the hearing, which began Monday and runs through Thursday in East St. Louis, Illinois, is critical for thousands of people with Parkinson’s who are suing paraquat maker Syngenta AG and former paraquat distributor Chevron.

The plaintiffs claim scientific research shows that exposure to paraquat significantly increases the risk of Parkinson’s disease, but instead of warning users the companies prioritized paraquat sales over human health. The first trial is scheduled to start in October.

When this week’s hearing concludes, US District Court Chief Judge Nancy Rosenstengel will determine whether or not the plaintiffs’ experts and their scientific analyses will be allowed as evidence in the upcoming trials. Syngenta and Chevron are asking the judge to bar each of the plaintiffs’ scientific experts from testifying, saying their experience is lacking and their analyses are deeply flawed. If the judge agrees, the plaintiffs’ cases could be virtually unwinnable.

More than 4,600 plaintiffs are part of the multidistrict litigation (MDL) being overseen by Rosenstengel. More cases are pending in different jurisdictions around the US.

Syngenta and Chevron deny paraquat causes Parkinson’s and are fighting the lawsuits. The companies say the weight of scientific evidence demonstrates no causal link between the chemical and the disease.

Plaintiff’s lawyers told the judge their case will rely in part on years of animal studies showing that paraquat interacts in the brain to kill specific cells in a manner that is a hallmark of Parkinson’s disease. Human studies also support their case, the lawyers said. When the cases go to trial, they plan to present testimony from several expert witnesses supporting their allegations.

On Tuesday, the hearing turned to testimony by one of those expert witnesses – Cornell professor of epidemiology Martin Wells. Under oath, Wells told the judge that his analysis of years of published research led him to conclude that people exposed to paraquat have a risk of developing Parkinson’s disease that is substantially higher than for people not exposed to the weed killer.

Wells calculated an odds ratio of 2.8 with respect to paraquat’s causal relationship to Parkinson’s disease, meaning the risk of disease resulting from paraquat exposure was 180 times higher than the odds absent that exposure.

August 20, 2023

Conflict of interest alleged in Roundup case in Monsanto’s home town

By Carey Gillam

Lawyers representing a man who blames his cancer on exposure to Monsanto’s Roundup weed killer are crying foul over what they say are close personal ties between a lead Monsanto lawyer and a special magistrate helping oversee the Roundup litigation.

In an Aug. 17 court filing, the plaintiffs’ attorneys asked for St. Louis County special master Robert Blitz to be disqualified from his role in the litigation because of an “appearance of impropriety” and questions about his impartiality.

A hearing on the matter is set for Tuesday.

There are dozens of plaintiffs named in the case, and all allege that exposure to Monsanto’s glyphosate-based Roundup herbicide caused them to develop non-Hodgkin lymphoma (NHL).

One of the plaintiffs, Mark McCostlin, of Lenexa, Kansas, is set to go to trial against Monsanto in St. Louis County Circuit Court in early September.

The motion alleges that Monsanto lead attorney James Bennett “has a close relationship” with special master Blitz. The two men worked together as co-counsel in a separate case, and Bennett also has personally acted as legal counsel for Blitz and for his law firm, according to the motion.

Additionally, the two men are “effectively economic partners” in a contingency fee case that brought their two law firms $276.5 million in fees, which they split, according to the motion.

“Their relationship creates a conflict of interest such that Blitz is not qualified to serve as special master in any case in which Bennett is trial counsel,” the motion states.