toxicology

February 15, 2024

Another pesticide problem on your plate

By Carey Gillam

Highlighting a fresh health concern for US consumers, a new study has found that a farm chemical linked to reproductive problems is increasingly showing up in the urine of people across the United States.

The study, published in the Journal of Exposure Science & Environmental Epidemiology on Thursday, reported that the majority of a set of nearly 100 urine samples collected from people in different states over the last few years showed the presence of a pesticide called chlormequat, which is used in agriculture to control growth in plants.

Notably, the study found that both frequency of detection and concentrations of the chemical were starkly higher in 2023 than in samples collected from prior years.

“While the sample size is small and more research will be needed to verify the extent of the problem, it is very concerning to see chlormequat chloride showing up in these samples, and at increasing levels,” said Danielle Melgar, a specialist in food and agriculture advocacy work with the Public Interest Research Group.

“It means that consumers are clearly being exposed to it. If it wasn’t linked to health concerns, that might not be an issue, but independent research has established connections to fetal and reproductive health harms in animal studies,” Melgar said.

Chlormequat is used to regulate the size of plants by blocking certain hormones. Though primarily used on ornamental plants in the United States, it is allowed on imported foods from other countries, including from Canada and Europe where chlormequat is approved for use on wheat, oats and barley.

Last year, the US Environmental Protection Agency (EPA) proposed that farmers in this country also be allowed to apply it to their food crops. By regulating the growth of crops such as wheat, yields can be improved, farmers have found.

But animal studies show chlormequat exposure can disrupt embryonic growth and contribute to other health problems.

Environmental and health advocates cite those studies in strongly opposing any expansion of use. Last year, PIRG sent a petition to the EPA, arguing “a slightly bigger harvest isn’t worth the risk to our health.”

October 25, 2023

Glyphosate cancer findings of “extreme concern” as Europe weighs reauthorization of pesticide

By Carey Gillam

European researchers have found new evidence linking popular weed killing products to cancer at levels currently considered safe.

The study focused on glyphosate, the active ingredient in Roundup herbicide and other brands, and is the latest of a series of studies examining the safety of the world’s most widely used weed-killing chemical.

Notably, the work comes as the European Union is wrestling over whether or not to keep glyphosate products on the market after the current approval expires in December.

The research has not yet been peer reviewed, but was presented Wednesday at an international scientific conference.

“We felt an urgency to present this data, and provide it to policy makers and the public,” said Daniele Mandrioli, director of the Ramazzini Institute in Bologna, Italy, which is overseeing a multi-faceted research program investigating glyphosate impacts called the Global Glyphosate Study.

“This is of extreme concern. We couldn’t sit on this data,” Mandrioli said.

Glyphosate is so widely used that it is ubiquitous in the environment- commonly found in food, water and human urine samples.

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June 2, 2023

Syngenta’s “SWAT” team- Internal files reveal secret strategies to influence science

By Carey Gillam
Global chemical giant Syngenta has sought to secretly influence scientific research regarding links between its top-selling weed killer and Parkinson’s, internal corporate documents show.

While numerous independent researchers have determined that the weed killer, paraquat, can cause neurological changes that are hallmarks of Parkinson’s, Syngenta has always maintained that the evidence linking paraquat to Parkinson’s disease is “fragmentary” and “inconclusive.”

But the scientific record they point to as proof of paraquat’s safety is one that Syngenta officials, scientists and lawyers in the US and the UK have worked over decades to create, and at times, covertly manipulate, according to the trove of internal Syngenta files reviewed by the The New Lede in a collaboration with The Guardian.

The files reveal an array of tactics, including enlisting a prominent UK scientist and other outside researchers who authored scientific literature that did not disclose any involvement with Syngenta; misleading regulators about the existence of unfavorable research conducted by its own scientists; and engaging lawyers to review and suggest edits for scientific reports in ways that downplayed worrisome findings.

The files also show that Syngenta created what officials called a “PQ SWAT team” to be ready to respond to new independent scientific reports that could interfere with Syngenta’s “freedom to sell” paraquat. The group, also referred to as Paraquat Communications Management Team,” was to convene “immediately on notification” of the publication of a new study, “triage the situation,” and plan a response, including commissioning a “scientific critique.”

A key goal was to “create an international scientific consensus against the hypothesis that paraquat is a risk factor for Parkinson’s disease,” the documents state.

In another example of a company tactic, an outside lawyer hired by Syngenta to work with its scientists was asked to review and suggest edits on internal meeting minutes regarding paraquat safety. The lawyer pushed scientists to alter “problematic language” and scientific conclusions deemed “unhelpful” to the corporate defense of paraquat.