University of California-San Francisco Program on Reproductive Health and the Environment

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December 16, 2024

Scientists call on federal regulators to rid US agencies of corporate influence

By Shannon Kelleher

Scientists are calling for the incoming Trump administration to adopt a set of guidelines designed to ensure scientific integrity at federal agencies and loosen corporate influence on regulators charged with protecting Americans’ health.

The recommendations, published Dec. 16, state that the US Environmental Protection Agency (EPA), the US Food and Drug Administration (FDA) and other agencies must eliminate financial and political conflicts of interest from environmental health research, halt industry influence on advisory boards and use the best available science to identify the health risks of toxic chemicals, which are contributing to the rise in chronic diseases such as cancer and diabetes.

Conflicts of interest that undermine the scientific process have resulted in “weakened chemical regulations, increased exposure to harmful chemicals, and greater risks to the health of families, workers, and communities,” the authors concluded.

“Our recommendations will not only strengthen the scientific frameworks of regulatory agencies but also enhance their ability to identify and mitigate toxic chemical exposures, protecting the health of all people who live in the US – especially those who are most susceptible to harm,” Rashmi Joglekar, director of science and policy at the University of California San Francisco Program on Reproductive Health and the Environment (PRHE), said in a press release. PRHE issued the guidelines.

The proposal has been endorsed by at least 48 scientists and public health experts and14 health and environmental organizations. Longer recommendations will be available in early January, said a spokesperson for PRHE.

The EPA and FDA said they plan to review the guidelines.

September 18, 2023

Certain common chemicals associated with higher odds of cancer in women

By Carey Gillam

Women exposed to several widely used chemicals appear to face increased odds for ovarian and other certain types of cancers, including a doubling of odds for melanoma, according to new research funded by the US government.

Using data collected by the Centers for Disease Control and Prevention (CDC), a team of academic researchers found evidence that women diagnosed with some “hormonally-driven” cancers had exposures to certain per- and polyfluoroalkyl substances (PFAS), which are used in thousands of household and industrial products, including in stain- and heat-resistant items.

They found similar links between women diagnosed with cancer and high exposures to phenols, which are commonly used in food packaging, dyes and personal care products.

The study, published late Sunday in the Journal of Exposure Science and Environmental Epidemiology, did not find similar associations between the chemicals and cancer diagnoses in men.

PFAS chemicals, in particular, may disrupt hormone functions specific to women – a potential mechanism for increasing their odds of hormone-related cancers, the researchers determined. Hormonally active cancers are common and hard to cure, making deeper inquiry into potential environmental causes critical, the researchers said.

“People should care about this because we know that there is widespread human exposure to these chemicals and we have documented data on that,” said Max Aung, assistant professor of environmental health at USC Kreck School of Medicine and a senior author of the study.

“These chemicals can increase the risk of various different health outcomes and they can alter your biological pathways… that is important to know so that we can better prevent exposures and mitigate risks,” Aung said.